Metronidazole treatment of acute diarrhea

Researchers evaluated the use of metronidazole administration in dogs with acute nonspecific diarrhea. Thirty-one dogs, including 14 test population dogs and 17 controls, were evaluated. Dogs with acute diarrhea of unconfirmed cause were randomly assigned to metronidazole treatment (10-15 mg/kg PO q12h for 7 days) or placebo.

The mean time to resolution of diarrhea for metronidazole dogs was 2.1 days while the time for resolution for controls was 3.6 days. Only 3 of 13 (23.1%) treated dogs had persistent C. perfringens at day 7, which was less than the 11 of 14 (78.6%) controls.

Results suggest that metronidazole treatment can shorten duration of diarrhea and decrease detection of C. perfringens in some dogs with acute nonspecific diarrhea.

Read more by clicking on the link below:

Metronidazole treatment of acute diarrhea in dogs: A randomized double blinded placebo-controlled clinical trial.

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