Researchers studied the effects of overfeeding cats. Eight cats were in the study. Four cats were fed twice their daily energy requirement with a commercial diet for 4 weeks. The control group was fed the estimated daily energy requirement with the same diet. Body weight, feline body mass index, body condition score, and plasma metabolites/hepatic injury marker were measured in all the cats before and after the experiment. Fatty acid profiles in the liver and subcutaneous adipose tissue were also measured.
Results
After 4 weeks of overfeeding, the experimental group demonstrated significant increases in hepatic C18:1, plasma triglyceride, and nonesterified fatty acid (NEFA) concentrations and in alanine aminotransferase activity. The hepatic SCD-1 indices were positively correlated with body weight, feline body mass index, body condition score, and plasma NEFA concentration, although subcutaneous adipose tissue did not demonstrate any increase in SCD-1 indices in this study.
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