A UK study evaluated ten cases of hepatic leptospirosis in dogs diagnosed by fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR), with the absence of clinically relevant renal involvement.

All ten cases had increased liver enzyme activities and confirmed infection with L. interrogans/kirschneri. Four dogs underwent repeat liver biopsy, FISH and PCR speciation 4-15 months after initial presentation and doxycycline treatment. Three of those dogs remained positive for L. interrogans/kirschneri infection. Four dogs were euthanized as a result of progressive liver disease.

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Hepatic leptospiral infections in dogs without obvious renal involvement.