Researchers evaluated EgKI-1, a potent Kunitz type protease inhibitor found in the canine tapeworm, Echinococcus granulosus . The inhibitor has shown anti-cancer activities in vivo. In this study, EgKI-1 is shown to significantly reduced the growth of melanoma in a mouse. The inhibitor was also shown to be non toxic to surrounding tissue. Study suggests that EgKI-1 can reduce tumor growth by inducing apoptosis and modulating the tumor microenvironment and has the potential for development as an intra-lesional treatment for melanoma.

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Kunitz type protease inhibitor from the canine tapeworm as a potential therapeutic for melanoma.